Abstract: Objective: To study the expression of tyrosine-kinase receptors(TRKs) and neurotrophins(NTs) in human neuroblastomas. Methods: Expression of TrkA, TrkB, TrkC and BDNF mRNA was semiquantitatively detected by reverse transcription-polymerase chain reaction in 27 cases of neuroblastomas. Results: The high and total rate of TrkA were expressed in significantly lower-stage group compared to higher-stage group(P<0.05) and the high level of TrkA expression was correlated positively with the two-year cumulative-survival rate of these patients(P<0.01). The high and total rate of TrkB were expressed in significantly higher-staging group compared to lower-staging group(P<0.05) and the three rates of BDNF expression in the two groups weren't statistically different (P<0.05), but the co-expression ratio of TrkB and BDNF showed a remarkable significance in higher-staging group more than lower-staging group(P<0.05). Expression of TrkC was usually accompanied by expression of TrkA and the co-expression ratio between them had a statistical significance in the lower-staging group compared to the higher-staging group (P<0.05), but there was only a non-significant trend between TrkC and TrkA expression. Conclusion: RT-PCR detection of TRKs and NTs has an important clinical significance of tumor stage and outcome for patients with neuroblastomas.